Date of Award
2025
Document Type
Thesis
Department
Biology
Mentor
Susan Manahan
Abstract
Celiac Disease is an allergic response to foods that contain the protein gluten. Celiac Disease is classified as an autoimmune disorder, which specifically deteriorates the villi of the jejunal segment of the small intestine. Specific topics analyzed within this thesis include some physical attributes of Celiac Disease such as weight loss, diarrhea, dermatitis herpetiformis, etc. The basis of classification is discussed and the negative effects Celiac Disease has on the body, such as malabsorption, vitamin deficiencies, and damage to the villi. Diagnostics such as biopsy and blood tests, treatments both experimental and adhering to a gluten-free diet are discussed. Origination of Celiac Disease in various countries and etiology from modification during agriculture are discussed, and certain populations at risk such as those with a genetic predisposition are analyzed. Physiological processes involving cancer and the effects of a gluten-free diet on healing Celiac Disease are mentioned. Findings indicated both negative physical and neurological symptoms relating to Celiac Disease, the damage Celiac Disease has on, the implications of malabsorption, the modification of gluten through time, how chances of having Celiac Disease increase with a genetic history, and the positive effects of a gluten-free diet in treating those with Celiac Disease.
Citation Information
Reece, Kendall N., "Pathogenesis and Pathophysiology of Celiac Disease" (2025). Undergraduate Honors Theses. 72.
https://digitalcommons.gardner-webb.edu/undergrad-honors/72