Date of Award
2025
Document Type
Capstone
Degree Name
Master of Science (MS)
Committee Chair
Trey Boyd
Abstract
Introduction: Pre-eclampsia is a leading cause of maternal mortality worldwide. The purpose of this clinical review is to analyze the efficacy of aspirin vs placebo in the prevention of pre- eclampsia in high-risk pregnant women.
Methods: PubMed, COCHRANE, and JAMA Network were searched with terms “pre- eclampsia” AND “prevention” AND “aspirin." Operators and filters were added to find RCTs, reviews, and meta-analyses within the last five years. One article was found using article reference searching. Four articles were chosen for review.
Results: One article was a randomized controlled trial comparing low dose aspirin against placebo in women identified as high risk for developing pre-term pre-eclampsia. The other three articles were systematic reviews and meta-analyses reviewing the evidence produced by large trials that compared the efficacy of aspirin vs placebo in the prevention of subgroups of pre- eclampsia. The subgroups were term vs pre-term pre-eclampsia and mild vs severe pre- eclampsia.
Conclusion: The articles reviewed produced mixed results. The administration of low dose aspirin(50-150mg) in high-risk women to prevent pre-eclampsia appears safe. The official recommendation of low dose aspirin administration for women at high risk of developing pre- eclampsia whether term or pre-term, remains in effect.
Recommended Citation
Walker, Nia, "Prophylactic Aspirin for the Prevention of Pre-Eclampsia in High-Risk Pregnant Women" (2025). The PA Department Journal of Medical Science. 29.
https://digitalcommons.gardner-webb.edu/pa-department-journal-of-medical-science/29
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