Date of Award

2025

Document Type

Capstone

Degree Name

Master of Science (MS)

Committee Chair

Trey Boyd

Abstract

Introduction: Secondary Mitral Regurgitation due to heart failure is a major cause of morbidity and mortality. There is debate about surgical versus medical treatment options. This paper aims to evaluate the efficacy of adding transcatheter mitral valve repair (TMVR) with standard treatments for heart failure.

Methods: Using Pubmed, the search terms “transcatheter mitral valve repair” AND “heart failure” resulted in 835 articles that were then filtered to <5 >years, English language, and type of article. This produced 22 articles that matched the search criteria. In total, 6 articles were used to analyze all-cause mortality and rehospitalization of heart failure patients receiving TMVR plus GDMT vs GDMT alone.

Results: Meta-analyses, RTCs, and systematic reviews were used to gather information on TMVR, including 3 articles that discussed the COAPT trial specifically. Two systematic reviews analyzing the COAPT trial showed decreased rates of mortality and rehospitalization 2 years and 5 years after implantation of the MitraclipTM. Two meta-analyses showed odds ratios that favored TMVR over GDMT alone for both mortality and rehospitalization.

Discussion: The studies included in this review suggest that TMVR plus GDMT is superior to GDMT alone for reducing all-cause mortality and rehospitalization in patients with heart failure. While additional factors influencing rehospitalization and mortality, such as cardiac complications and comorbidities are acknowledged, this review focuses specifically on the comparative outcomes of all-cause mortality and rehospitalization solely.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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