Date of Award

2025

Document Type

Capstone

Degree Name

Master of Science (MS)

Department

Physician Assistant Studies

Committee Chair

Trey Boyd

Abstract

Introduction: End-stage renal disease (ESRD) is a worldwide issue that occurs when the kidneys fail to filter out harmful waste from the blood. The only treatment options for patients with this diagnosis are kidney transplant, hemodialysis (HD), and peritoneal dialysis (PD). HD involves surgical prep with vascular access and is only performed in clinic. HD is also the most commonly used form of renal replacement therapy (RRT). Peritoneal dialysis is performed through the peritoneum and can be done in clinic or at home. The purpose of this paper is to investigate the overall patient outcomes in those undergoing HD compared to PD.

Methods: PubMed was searched with the terms “end-stage renal disease” “kidney failure” “peritoneal dialysis” and “hemodialysis”. Operators and filters narrowed results to 6 relevant, quality articles to review.

Results: 4 articles were systematic reviews and meta-analysis exploring variable factors of patients’ outcomes. One article was a randomized, non-inferiority trial investigated the burden of different RRTs. The final article is a small study performed investigating neurological impacts of RRT. Overall, when assessing quality of life outcomes, PD was favored.

Discussion: The articles reviewed produced mixed results. PD appears to have better patient outcomes in terms of quality of life but does not appear to be the superior option of care in dialysis patients. While results indicated a slight preference for PD, overall results are inconclusive on the superiority of one method compared to the other. Further research is needed.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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