Date of Award

2024

Document Type

Capstone

Degree Name

Master of Science (MS)

Committee Chair

Trey Boyd

Abstract

Introduction: Dupuytren's contracture is a debilitating hand condition characterized by progressive contracture of the palmar fascia. The use of collagenase clostridium histolyticum injections has emerged as a minimally invasive alternative to surgical interventions, with varying degrees of efficacy and safety compared to traditional methods like limited fasciectomy and percutaneous needle fasciotomy.

Methods: A comprehensive literature review was conducted using PubMed to assess the efficacy and safety of collagenase injections for treating Dupuytren's contracture. The search focused on peer-reviewed randomized controlled trials, systematic reviews, and meta-analyses published in the last five years. Five relevant studies were selected based on the robustness of their data and relevance to the research question.

Results: The studies reviewed demonstrated that while collagenase clostridium histolyticum offers a less invasive treatment with quicker recovery times, they are associated with higher recurrence rates and more frequent minor complications compared to other options. Limited fasciectomy showed the greatest improvement in range of motion and the lowest recurrence rates but carried a higher risk of severe complications such as nerve injury. Percutaneous needle fasciotomy, although slightly less effective in range of motion improvement, had fewer complications, making it a safer option for patients with milder conditions.

Discussion: The choice of treatment for Dupuytren's contracture should be tailored to the patient's condition severity and personal priorities. Further research is needed to refine these recommendations and explore the long-term effects of these treatments on quality of life.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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