Date of Award

2023

Document Type

Thesis

Department

Chemistry

Mentor

Venita Totten

Abstract

Human pharmacokinetics is the study of how administered medications move throughout and behave within the body. Absorption, distribution, metabolism, and excretion are four integral parts of this field of study and are commonly known as the ADME principles of pharmacokinetics, but other processes are studied within the field. For orally administered drugs, the absorption process lies within the small intestine and colon, two components of the gastrointestinal (GI) tract; this bodily system is associated with many variables––many of which must be considered in the study of oral drug absorption. Often administered orally, non-steroidal anti-inflammatory drugs (NSAIDs) make up a group rich in history that includes a plethora of drugs available today. NSAIDs are typically known for their treatment of inflammation, pain, and fever, and ibuprofen is a well-known NSAID that treats all three of these afflictions. Ibuprofen is a relatively recent component of the NSAID group, but published research regarding this drug’s associated adverse reactions and pharmacokinetic behavior is plentiful. Important factors in ibuprofen’s pharmacokinetic behavior include age, biological sex, and body composition; most importantly, the impact of food consumption on oral ibuprofen absorption is an essential consideration when this drug is administered, for a common belief surrounding ibuprofen is that it must be taken with food. Overall, this literature review aimed to compile published information necessary to understand the pharmacokinetics of ibuprofen, discuss important variables in this NSAID’s pharmacokinetic behavior, and evaluate ibuprofen’s associated food effect­­––and apply it to patient safety and treatment efficacy.

Creative Commons License

Creative Commons Attribution-Noncommercial 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License

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